Published Science 

Papers

Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation. WT Hsu, DA Ramirez, T Sammakia, Z Tan, MR Shirts. 2022 May. J Comput Aided Mol Des.

Cannabidiol induces apoptosis and perturbs mitochondrial function in human and canine glioma cells. C Gross, DA Ramirez, S McGrath, DL Gustafson. 2021 Aug. Front Pharmacol.

Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells. L Pezzanite, L Chow, G Piquini, G Griffenhagen, DA Ramirez, S Dow, L Goodrich. 2020 May. Equine Vet J. Link here.

First-in-class inhibitors of oncogenic CHD1L with preclinical activity against colorectal cancer. JM Abbott, Q Zhou, H Esquer, L Pike, TP Broneske, S Rinaldetti, A Abraham, DA Ramirez, PJ Lunghofer, T Pitts, DP Regan, AC Tan, DL Gustafson, WA Messersmith, DV LaBarbera. 2020 May. Mol Cancer Ther. Link here.

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. H Zhou, M Blevins, J Hsu, D Kong, M Galbraith, A Goodspeed, R Culp-Hill, M Oliphant, DA Ramirez, L Zhang, J Pineiro, LM Greiner, R King, E Barnaeva, X Hu, N Southall, M Ferrer, D Gustafson, D Regan, A D'Alessandro, J Costello, S Patnaik, J Marugan, R Zhao, H Ford. 2020 April. Cancer Res. Link here.

Drug design targeting T-cell factor-driven epithelial-mesenchymal transition as a therapeutic strategy for colorectal cancer. AD Abraham, H Esquer, Q Zhou, N Tomlinson, BD Hamill, JM Abbott, L Li, LA Pike, S Rinaldetti, DA Ramirez, PJ Lunghofer, JD Gomez, J Schaack, T Nemkov, A D'Alessandro, KC Hansen, DL Gustafson, WA Messersmith, DV LaBarbera. 2019 Nov 27. J Med Chem. DOI: 10.1021/acs.jmedchem.9b01065. Link here.

Kinetics of cyclophosphamide metabolism in human, dog, cat, and mouse and relationship to cytotoxic activity and pharmacokinetics. DA Ramirez, KP Collins, AE Aradi, KA Conger, and DL Gustafson. 2019 Mar 1. Drug Metab Disp. doi.org/10.1124/dmd.118.083766. Link here.

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Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers. LA Wittenburg, K Weishaar, DA Ramirez, and DL Gustafson. 2019 Jan 14. Vet Comp Oncol. doi: 10.1111/vco.12455. Link here.

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Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method. LA Wittenburg, DA Ramirez, H Conger, and DL Gustafson. 2018 Nov 12. Vet Science. doi: 10.1016/j.rvsc.2018.11.009. Link here.

In Vivo and In Vitro Assessment of Mirtazapine Pharmacokinetics in Cats with Liver Disease. RL Fitzpatrick, JM Quimby, KK Benson, DA Ramirez, L Sieberg, LA Wittenburg, and DL Gustafson. 2018 Oct 11. J Vet Intern Med. doi: 10.1111/jvim.15237. Link here.

Accepted Abstracts

Cannabidiol induces apoptosis and perturbs mitochondrial function in both human and canine glioma cells. Chase Gross, Dominique Ramirez, Peter Dickinson, Daniel Gustafson, Stephanie McGrath. Accepted for Experimental Biology 2020. Scheduled for publication in FASEB April 2020.

Novel small molecule compound disrupts the SIX1/EYA2 complex and inhibits breast cancer metastasis. Hengbo Zhou, … Dominique Ramirez, … Heide Ford. Accepted for Experimental Biology 2020. Scheduled for publication in FASEB April 2020.

Presented Posters

In vitro cytotoxic effects of cannabidiol on canine melanoma and glioma cells. Chase Gross, Reed H Schultz, Katie Stone, Dominique Ramirez, Daniel L. Gustafson, Stephanie McGrath. Presented at: 2019 Boehringer Ingelheim National Veterinary Scholars Symposium, Worchester, MA.

Vinca alkaloid pharmacokinetics in the context of a physiologically-based murine model. Keagan P. Collins, Joshua D. Mannheimer, Dominique A. Ramirez, Daniel L. Gustafson. Presented at: 2018 ASPET Annual Meeting, San Diego, California.

Determining the Preferential Phase II Metabolic Pathway for Structural Isomers of Endoxifen. Dominique Ramirez, Sarah Buhrow, Joel Reid. Presented at: CSU Honors Visiting Scholar Symposium. Visiting Scholar: Joan Steitz. Presented at: Mayo Clinic Undergraduate Research Symposium. (2016)

Simultaneous absolute quantitation of ATP-binding cassette transporters in canine tissues via targeted proteomics. Luke A Wittenburg, Holly Conger, Dominique Ramirez, Daniel Gustafson.
Presented at: National AACR Meeting, New Orleans, Louisiana. (2016)

Chemotherapeutic Responses in Canine Lymphoma Models After Treatment with the CHOP Protocol. Dominique Ramirez, Luke A Wittenburg.
Presented at: CSU CURC. College Honors Award Recipient. (2016)